Domoic acid as a neurotoxin

A Pérez-Gómez, RA Tasker - Handbook of neurotoxicity, 2023 - Springer
Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione
deficiency. Molecular … Glutathione levels modulate domoic acid induced apoptosis in mouse …

Glutamatergic Neurotransmission and Toxicity: Domoic Acid and Kainic Acid (Glutamic Acid Analogs)

EK Pope, LJ Bigelow, PB Bernard - 2024 - books.rsc.org
… ), and antioxidants (eg, glutathione). While glutamate is most well … names match their
corresponding genes. It is therefore … may help to explain its increased neurotoxicity. Additionally, …

Domoic acid

RA Tasker - Advances in Neurotoxicology, 2021 - Elsevier
Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione
deficiency… enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-…

Toxic effects of domoic acid on Caenorhabditis elegans and the underlying mechanism

D Tian, G Zhang - International Journal of Biology, 2019 - public.paper4promo.com
… elegans), a classical model organism used in biomedical … to be a sensitive endpoint for
neurotoxicity, which is consistent with … We thank the Caenorhabditis Genetics Center for providing …

Transcriptional Response in the Digestive Gland of the King Scallop (Pecten maximus) After the Injection of Domoic Acid

P Ventoso, AJ Pazos, J Blanco, ML Pérez-Parallé… - Toxins, 2021 - mdpi.com
Genes that code for cytochrome P450 enzymes, glutathione S… role against glutamate
neurotoxicity in neural tissues [60,61], … (cerebral, pedal, and parietovisceral ganglia) of P. …

Effect of microcystin-LR, nodularin, anatoxin-a, β-N-methylamino-L-alanine and domoic acid on antioxidant properties of glutathione

M Adamski, A Kaminski - Life, 2022 - mdpi.com
… cyanotoxin action resulting in depletion of GSH concentration … of this toxin involved the
depletion of the GSH concentration … GSH metabolism in mice cerebellar granule neurons (CGNs). …

RNA-Seq Transcriptome Profiling of the Queen Scallop (Aequipecten opercularis) Digestive Gland after Exposure to Domoic Acid-Producing Pseudo-nitzschia

P Ventoso, AJ Pazos, ML Pérez-Parallé, J Blanco… - Toxins, 2019 - mdpi.com
… and differential gene expression in a scallop under domoic acid … mechanisms of the
neurotoxicity of domoic acid in vertebrates (… that glutathione S-transferases play a role in domoic

[PDF][PDF] White Matter Tractography and Neurohistopathology after Chronic, Low-Level Exposure to Domoic Acid in a Nonhuman Primate Model

R Petroff, GJ Harry, T Richards… - … Domoic Acid …, 2020 - digital.lib.washington.edu
… dissertation suggest that DA exposure in the nonhuman primate model, even at levels that
are currently safe for human consumption, is linked to neurotoxic effects in key regions of the …

Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain

JM Garrick, K Dao, LG Costa, J Marsillach… - BMC neuroscience, 2022 - Springer
… We found alterations in multiple key dopaminergic genes at … neurons, and we sought to
determine if PON2 deficiency … and dopaminergic neuron sensitivity to the neurotoxic compound …

[图书][B] Developmental Neurotoxicity of Diesel Exhaust in a Gclm Heterozygous Mouse Model

AR Phillips - 2022 - search.proquest.com
gene-environment interaction for effects on the neurodevelopmental toxicity of DE, we used
… are more representative of the human population and are the ideal model to study this gene- …